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. 2011 Oct 12;73(4):588–596. doi: 10.1111/j.1365-2125.2011.04117.x

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© 2011 The Authors. British Journal of Clinical Pharmacology © 2011 The British Pharmacological Society

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Percentage of the ceftazidime simulated concentrations in the 40–100 mg l⁻¹ target interval after 24 h (A and B) and 72 h (C and D) for a 2 g x 3 day^–1 (A and C) and a 2 g loading dose + 6 g continuous infusion (B and D) in patients with (I1) or without (I0) mechanical ventilation as a function of MDRD in ml min⁻¹. The admitting diagnoses were: P0 = polytrauma, P1 = post surgical and P2 = medical reason. The vertical colour lines correspond to the mean glomerular filtration rate estimated by MDRD in these three subpopulations. I0P0 (); I0P1 (); I0P2 (); I1P0 (); I1P1 (); I1P2 ()

Inline graphic — Percentage of the ceftazidime simulated concentrations in the 40–100 mg l⁻¹ target interval after 24 h (A and B) and 72 h (C and D) for a 2 g x 3 day^–1 (A and C) and a 2 g loading dose + 6 g continuous infusion (B and D) in patients with (I1) or without (I0) mechanical ventilation as a function of MDRD in ml min⁻¹. The admitting diagnoses were: P0 = polytrauma, P1 = post surgical and P2 = medical reason. The vertical colour lines correspond to the mean glomerular filtration rate estimated by MDRD in these three subpopulations. I0P0 (); I0P1 (); I0P2 (); I1P0 (); I1P1 (); I1P2 ()