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. Author manuscript; available in PMC: 2012 Jun 18.
Published in final edited form as: Nat Rev Genet. 2012 Feb 14;13(3):204–214. doi: 10.1038/nrg3152

Figure 4. Deducing the strand on which mutations arise.

Figure 4

In the absence of uracil removal, deamination of C on the nontranscribed strand (NTS) leads to C > T mutations (note: by convention, DNA sequences are read from the NTS, which has the same sequence as the mRNA). In contrast, deamination of C on the transcribed strand results in G > T mutations.