Table 1.

GWAS, Case-Control Replication Study, and Metaanalysis Results for Significant SNPs

Independencea	Alleleb	Stage	Case	Ctrl	ORc	p Valuec	HWEd	Statuse	Qf	I2f	ORg	p Valueg	ORh	p Valueh
Chromosome 6, rs498422
Yes	G/T	GWAS	0.20	0.13	1.81	1.53 × 10−11	0.36	G/I	0.006	80.12	1.42	2.43 × 10−12	1.44	1.8 × 10−3
		replication 1	0.17	0.13	1.37	1.46 × 10−4
		replication 2	0.16	0.14	1.21	0.068
Chromosome 6, rs2076531
No	G/A	GWAS	0.11	0.06	2.03	1.49 × 10−9	0.67	I/G	0.04	67.84	1.61	6.60 × 10−13	1.60	1.4 × 10−4
		replication 1	0.10	0.07	1.42	9.75 × 10−4
		replication 2	0.08	0.06	1.40	0.018
Chromosome 6, rs3129878
Yes	C/A	GWAS	0.40	0.29	1.63	1.03 × 10−12	0.74	G/G	0.005	81.07	1.37	3.70 × 10−16	1.36	9.0 × 10−4
		replication 1	0.36	0.30	1.32	1.48 × 10−5
		replication 2	0.32	0.28	1.17	0.051
Chromosome 6, rs7192
No	T/G	GWAS	0.32	0.26	1.42	1.02 × 10−6	0.58	G/I	0.19	39.42	1.28	1.10 × 10−9	1.29	2.9 × 10−6
		replication 1	0.32	0.27	1.26	3.70 × 10−4
		replication 2	0.29	0.26	1.17	0.050

Ctrl, control; OR, odds ratio; HWE, Hardy-Weinberg equilibrium.

^a“Independence” indicates whether the SNPs remained independently associated with NOA risk when adjusted for the other SNPs in the model.

^bMinor allele/major allele.

^cOR is estimated on the basis of the minor allele; OR and p values are estimated on the basis of logistic regression analysis, adjusted for age and the first two eigen vectors, estimated on the basis of principal component analysis.

^dHWE tests were based on Fisher's exact tests in the combined control subjects.

^eG, genotyped; I, imputed. The letter before the forward slash indicates the imputation status for cases, and the letter after the forward slash indicates the imputation status for controls.

^fThe p values of Q test and I2 values are based on tests for heterogeneity.

^gThe combined analysis was based on logistic regression analysis, adjusted for age and stage information.

^hThe combined analysis was based on metaanalysis, with the assumption of a random effect model.