Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Protein evolution in vitro. Minimization of the three-helix bundle Z domain into a two-helix bundle that maintains equivalent function with half the size. Z, natural three-helix domain. ΔZ, starting 38-residue truncated peptide. Z38, selected two-helix binding domain. Z34C, further truncated 34-residue peptide with engineered disulfide bond. Blue, hydrophilic amino acids; red, hydrophobic amino acids; green, disulfide bond.
