Table 1.
Biodistribution of 99mTc-N4 in mammary tumor-bearing rats.
| % of injected dose per gram of tissue weight | |||
|---|---|---|---|
| (n = 3/time, interval, iv) | |||
| 30 min | 120 min | 240 min | |
| Blood | 0.23 ± 0.009 | 0.04 ± 0.002 | 0.02 ± 0.002 |
| Heart | 0.07 ± 0.005 | 0.01 ± 0.001 | 0.01 ± 0.000 |
| Lung | 0.20 ± 0.011 | 0.05 ± 0.002 | 0.03 ± 0.001 |
| Thyroid | 0.25 ± 0.011 | 0.03 ± 0.002 | 0.02 ± 0.001 |
| Pancreas | 0.07 ± 0.007 | 0.02 ± 0.002 | 0.02 ± 0.001 |
| Liver | 2.98 ± 0.083 | 1.14 ± 0.018 | 0.79 ± 0.026 |
| Spleen | 0.35 ± 0.026 | 0.37 ± 0.007 | 0.39 ± 0.020 |
| Kidney | 2.56 ± 0.101 | 1.11 ± 0.045 | 0.65 ± 0.028 |
| Stomach | 0.12 ± 0.005 | 0.02 ± 0.001 | 0.01 ± 0.000 |
| Intestine | 0.25 ± 0.004 | 0.39 ± 0.048 | 0.14 ± 0.003 |
| Uterus | 0.16 ± 0.014 | 0.02 ± 0.001 | 0.01 ± 0.001 |
| Tumor | 0.09 ± 0.004 | 0.03 ± 0.003 | 0.02 ± 0.001 |
| Muscle | 0.05 ± 0.002 | 0.01 ± 0.000 | 0.01 ± 0.000 |
| Bone | 0.07 ± 0.001 | 0.02 ± 0.001 | 0.01 ± 0.000 |
| Brain | 0.01 ± 0.000 | 0.00 ± 0.000 | 0.00 ± 0.000 |
| Tumor/blood | 0.40 ± 0.002 | 0.78 ± 0.044 | 0.70 ± 0.008 |
| Tumor/muscle | 1.96 ± 0.015 | 5.32 ± 0.402 | 3.35 ± 0.147 |
| Tumor/brain | 6.19 ± 0.365 | 11.06 ± 0.667 | 11.93 ± 0.675 |
Value shown represents the mean ± standard deviation of data from 3 animals.