Table 2.
Biodistribution of 99mTc-N4-NIM in mammary tumor-bearing rats.
| % of injected dose per gram of tissue weight | |||
|---|---|---|---|
| (n = 3/time, interval, iv) | |||
| 30 min | 2 h | 4 h | |
| Blood | 0.76 ± 0.06 | 0.20 ± 0.01 | 0.16 ± 0.01 |
| Heart | 0.26 ± 0.03 | 0.07 ± 0.01 | 0.04 ± 0.00 |
| Lung | 0.58 ± 0.06 | 0.17 ± 0.00 | 0.10 ± 0.00 |
| Thyroid | 0.71 ± 0.06 | 0.17 ± 0.01 | 0.08 ± 0.00 |
| Pancreas | 0.22 ± 0.03 | 0.06 ± 0.00 | 0.04 ± 0.01 |
| Liver | 0.88 ± 0.05 | 0.84 ± 0.03 | 0.51 ± 0.02 |
| Spleen | 0.74 ± 0.13 | 0.42 ± 0.01 | 0.70 ± 0.02 |
| Kidney | 4.92 ± 0.89 | 4.42 ± 0.06 | 1.33 ± 0.10 |
| Stomach | 0.37 ± 0.04 | 0.09 ± 0.01 | 0.03 ± 0.00 |
| Intestine | 0.33 ± 0.04 | 0.15 ± 0.07 | 0.04 ± 0.01 |
| Uterus | 0.61 ± 0.16 | 0.20 ± 0.11 | 0.08 ± 0.01 |
| Tumor | 0.52 ± 0.02 | 0.20 ± 0.00 | 0.08 ± 0.00 |
| Muscle | 0.18 ± 0.01 | 0.04 ± 0.00 | 0.02 ± 0.00 |
| Bone | 0.22 ± 0.08 | 0.14 ± 0.02 | 0.03 ± 0.00 |
| Brain | 0.04 ± 0.00 | 0.01 ± 0.00 | 0.01 ± 0.00 |
| Tumor/blood | 0.69 ± 0.02 | 1.01 ± 0.05 | 0.98 ± 0.06 |
| Tumor/muscle | 2.86 ± 0.19 | 5.69 ± 0.40 | 4.88 ± 0.56 |
| Tumor/brain | 12.74 ± 2.26 | 15.51 ± 2.16 | 15.10 ± 2.47 |
Values shown represent the mean ± standard deviation of data from 3 animals.