Table II.

The concentrations (ng/g, mean ± SEM) of progesterone (P), DHP, 3α,5α-THP and progesterone utilisation (DHP + 3α,5α-THP:P ratio) in the hippocampus, medial prefrontal cortex and diencephalon of pubertal male and female offspring of mothers that were exposed to IL-1β (1 μg/rat) or vehicle (saline 0.9%) on GD 17–21.

	Brain concentrations of progestogens in the offspring (ng/g, mean ± SEM)
	Control		IL-1β
	Male (n = 12)	Female (n = 12)	Male (n = 9)	Female (n = 8)
Hippocampus
Progesterone	0.7 ± 0.2	0.3 ± 0.1	0.6 ± 0.4	0.6 ± 0.1
DHP	0.6 ± 0.2	0.3 ± 0.2	1.8 ± 0.1☆	0.7 ± 0.2
3α,5α-THP	0.8 ± 0.2	1.3 ± 0.4	1.5 ± 0.6	0.5 ± 0.4
P utilisation	6.1 ± 2.3	14.9 ± 5.0	6.1 ± 1.0	1.6 ± 0.4☆
Medial prefrontal cortex
Progesterone	0.3 ± 0.1	0.4 ± 0.1†	0.4 ± 0.1	0.7 ± 0.1†
DHP	0.2 ± 0.1	0.1 ± 0.1	0.4 ± 0.2	0.3 ± 0.1
3α,5α-THP	0.3 ± 0.1	2.8 ± 1.3	0.7 ± 0.3	1.3 ± 0.7
P utilisation	2.6 ± 0.7	9.6 ± 3.8	2.8 ± 0.8	2.2 ± 0.8
Diencephalon
Progesterone	0.2 ± < 0.0	0.3 ± 0.1	0.4 ± 0.1‡	0.3 ± < 0.0‡
DHP	0.2 ± 0.1	0.3 ± 0.1	0.8 ± 0.1‡	0.5 ± 0.1‡
3α,5α-THP	0.5 ± 0.2	0.7 ± 0.5	1.0 ± 0.5	0.3 ± 0.2
P utilisation	8.2 ± 4.5	10.3 ± 3.5	4.4 ± 0.8	2.2 ± 0.4

^☆Indicates a significant interaction in two-way ANOVA wherein the noted male or female groups significantly differ from respective controls, p < 0.05;

^†Indicates a main effect in two-way ANOVA for a significant difference between males and females, p < 0.05;

^‡Indicates a main effect in two-way ANOVA of prenatal IL-1β exposure compared with control offspring, p < 0.05.