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Effect of JCM-16021 on mucosal SERT expression in PI-IBS rats. (a) shows the immunofluorescence micrographs of (A1) negative control (primary antibody omitted) and the positive SERT expressions (arrowhead) in the mucosa of (A2) normal rats, (A3) PI-IBS rats, and (A4) high dose JCM-16021 treated rats (Scale bar, 200 μm). Statistical analysis of intensity of SERT immunoreactivity is shown in (b). Data are shown as mean ± S.E.M., n = 5 per group. **P < 0.01 versus normal rats (t-test).
