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. 2012 Jun 10;2012:239638. doi: 10.1155/2012/239638

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Copyright © 2012 Hong-Yan Qin et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of JCM-16021 on mechanical stimuli (CRD) induced 5-HT release in PI-IBS rats. (a) shows the statistical analysis of colonic 5-HT content in PI-IBS rats with or without CRD treatment. (b) shows the representative electron microsgraphs of EC cells and their secretory granules (inset) from the (B1) normal rats, (B2) PI-IBS rats, and (B3) high dose JCM-16021 treated rats (×8900; inset: ×10000). Activated EC cell is characterized by the clear secretory granules without cores (red arrow), or secretory granules with eccentric cores (red arrowhead) in it. Data are shown as mean ± S.E.M., n = 5 per group. *P < 0.05, **P < 0.01 versus the same group without CRD treatment (t-test).