Fig. 7.
Strophanthidin-sensitive NKA activity in PLN-WT and PLN-R14Del hearts. (A): Total ATPase activity was increased in R14del cardiac homogenates under basal conditions or in the absence of an inhibitor. ATPase activities in the presence of strophanthidin, a specific NKA inhibitor, were similar between PLN-WT and PLN-R14Del hearts, suggesting that the increase in basal total ATPase activity was not due to the contribution of other ATPases but an increase in NKA. (B): NKA activity was calculated by subtracting the ATPase activity in the presence of inhibitor from the activity in the absence of inhibitor. The average of NKA activity in PLN-R14Del heart homogenates was expressed as a fold-increase over PLN-WT for each paired sample. n=7. *, p<0.05.
