Figure 6.

Time course of the impedance (a), acidification (b) and respiration (c) of L6 rat skeletal muscle cells during 24 h incubation with Acetaminophen in the Bionas 2500 Analyzing System. Vehicle control (black), 4.530 mg/L (30 mM, red), 1.510 mg/L (10 mM, blue), 755 mg/L (5 mM, green), 151 mg/L (1 mM, yellow) and 75.5 mg/L (0.5 mM, grey). Phases with running medium (RM) represent culture medium treatment without added substances. (d) Percent of control of impedance, respiration and acidification endpoint values measured after 15 h of AAP exposure (n = 3). (e) Results of BrdU assay of L6 cells incubated with AAP for 24 h.