Table 1.
Frequency of FADS Haplotypes in European Populationsa
| Haplotype |
SNP |
Frequency (%) | Association (p Value) |
|---|---|---|---|
| 1234567890123456789012345678 | |||
| D | CCCTCGTTAATCTTAAAAACCACCCTAG | 62.1 | 1 × 10−65 |
| A | agtcgaccggctccgggggttgaaaaga | 33.0 | 1 × 10−52 |
| M1 | CgtcCGccggTCTTggAggttgaaaaga | 2.8 | 3 × 10−04 |
| M2 | agtcgaccggctccgggggttgaCaaga | 0.5 | 9 × 10−02 |
| M3 | agtcgaccggTtccgggggttgaaaaga | 0.3 | 2 × 10−01 |
| M4 | CCCTCGTTAATCTTAAAAACCgaaaaga | 0.2 | 4 × 10−02 |
| Total frequency | 98.9 | ||
The haplotypes are defined by 28 SNPs in block 1. The association between FADS haplotypes and lipid levels (PC 36:4) in the five European cohorts is shown in the far right column. Nucleotides on haplotypes D and A are represented by uppercase and lowercase letters, respectively.
a
From the European Special Population Research Network (EUROSPAN).