Table 2.
Associations between FADS Haplotypes and PUFAs in the NSHPS Cohort
| Common Name | p Value (mmscore)a | Effect of Haplotype D | |
|---|---|---|---|
| Omega-6 | |||
| FA18:2(n-6) | LA | 0.052 | −0.12 |
| FA18:3(n-6) | GLA | 1.3 × 10−18 | 0.56 |
| FA20:3(n-6) | DGLA | 0.26 | 0.07 |
| FA20:4(n-6) | AA | 5.2 × 10−18 | 0.50 |
| Ratio GLA/LAb | 1.6 × 10−27 | 0.68 | |
| Ratio AA/DGLAb | 1.8 × 10−11 | 0.40 | |
| Omega-3 | |||
| FA18:3(n-3) | ALA | 0.024 | −0.14 |
| FA20:4(n-3) | ETA | 2.2 × 10−05 | −0.25 |
| FA20:5(n-3) | EPA | 1.1 × 10−12 | 0.37 |
| FA22:6(n-3) | DHA | 8.3 × 10−05 | 0.20 |
| Ratio ETA/ALAb | 0.042 | −0.12 | |
| Ratio EPA/ETAb | 1.0 × 10−24 | 0.61 | |
The p values represent significance of differences in PUFA levels and have been corrected for relatedness between individuals. The following abbreviations are used: LA, linoleic acid; GLA, gamma-linoleic acid; DGLA, dihomo-gamma-linoleic acid; AA, arachidonic acid; ALA, alpha-linoleic acid; ETA, eicosatetraenoic acid; EPA, eicosapentaenoic acid; and DHA, docosahexaenoic acid.
a
Mixed model to adjust for relatedness among individuals; Bonferroni-adjusted p values.
b
Ratios (product/substrate) for the FADS1- or FADS2-catalyzed steps in fatty-acid synthesis.