Table 2. Baroregulation in NOS Inhibition Rats (N=14).
Tabulation of choroidal blood flow during spontaneous fluctuation in arterial blood pressure in the 12 rats analyzed that had been treated with the NOS inhibitors LNAME or NPA. The mean ABP for each 5, 10 or 20 mmHg step in pressure was determined, as was the mean ChBF at each ABP step. The first column shows the ABP ranges into which data samples were grouped. The subsequent columns show the number of animals per range, the number of data samples per animal for each range, the mean ABP (± SEM) per range (in mmHg), the mean ChBF (± SEM) per range (in BFUs), the mean ABP per range expressed as a percent of basal ABP (taken as the mean ABP in the 90-100 mmHg bin), the mean ChBF per range expressed as a percent of basal ChBF (taken as the mean ChBF during ABP in the 90-100 mmHg range), and the mean choroidal resistance per ABP range expressed as a percent of basal resistance (taken as resistance during ABP in the 90-100mmHg range). As can be seen for the NOS inhibition rats, ChBF values were as would be predicted if ChBF passively followed ABP in the low ABP range, but consistently lower than expected (and around 100% of basal) if ChBF passively followed ABP in the high ABP range. Resistance increased linearly above 100 mmHg, but remained near basal resistance (expressed as 100%) below 90 mmHg.
| Normal ABP Range | Rats per ABP Range | Mean BP-ChBF Samples per Rat | Mean ABP ± SEM per ABP Range | Mean ChBF ± SEM per ABP Range | Mean ABP per ABP Range as % of basal ABP | Mean ChBF per ABP Range as % of basal ChBF | ChBF Resistance per ABP Range as % of basal |
|---|---|---|---|---|---|---|---|
| 160-140 | 2 | 15.5 | 151.89±2.04 | 11.43±2.85 | 159.47% | 80.63% | 204.48% |
| 130-140 | 4 | 4.8 | 135.50±1.30 | 14.84±2.79 | 142.26% | 104.73% | 148.34% |
| 120-130 | 6 | 3.1 | 125.11±1.09 | 14.60±1.11 | 131.35% | 103.03% | 130.53% |
| 110-120 | 6 | 4.2 | 114.42±1.11 | 13.90±0.87 | 120.13% | 98.08% | 114.61% |
| 100-109 | 10 | 6.1 | 104.45±0.62 | 14.68±1.68 | 109.66% | 103.60% | 116.37% |
| 90-100 | 7 | 8.3 | 95.24±0.64 | 14.17±1.62 | 100.00% | 100.00% | 106.75% |
| 85-90 | 5 | 11.0 | 86.16±1.29 | 11.18±1.09 | 90.46% | 78.89% | 119.05% |
| 80-85 | 5 | 6.8 | 82.19±0.35 | 12.51±1.28 | 86.29% | 88.25% | 101.20% |
| 75-80 | 4 | 5.6 | 76.64±0.28 | 12.51±1.72 | 80.47% | 88.26% | 102.44% |
| 70-75 | 1 | 4.0 | 73.80 | 10.48 | 77.48% | 73.98% | 104.72% |
| 65-70 | 2 | 6.5 | 65.12±1.61 | 10.40±0.37 | 68.37% | 73.38% | 93.18% |
| 60-65 | 1 | 28.0 | 62.72 | 10.69 | 65.86% | 75.46% | 87.27% |
| 55-60 | 1 | 1.0 | 57.56 | 8.73 | 60.43% | 61.60% | 98.10% |
| 50-55 | 0 | ||||||
| 45-50 | 0 | ||||||
| 40-45 | 0 | ||||||
| 35-40 | 0 | ||||||
| 30-35 | 0 | ||||||
| 25-30 | 0 | ||||||
| 20-25 | 0 |