Table 2. Relative Risk Estimated for Prostate Cancer According to Circumcision Status, by Disease Aggressiveness #.
| All | Less Aggressive PCa | More Aggressive PCa | |||||
|---|---|---|---|---|---|---|---|
| Cases N (%) |
Controls N (%) |
OR* (95% CI) |
Cases ˆ N (%) |
OR * (95% CI) |
Cases ˆ N (%) |
OR* (95% CI) |
|
| Circumcision status (1) | |||||||
| No | 547 (31.2) | 469 (28.5) | 1.00 (Referent) | 351 (30.2) | 1.00 (Referent) | 196 (33.1) | 1.00 (Referent) |
| Yes | 1,207 (68.8) | 1,176 (71.5) | 0.87 (0.74 – 1.02) | 811 (69.8) | 0.91 (0.76 – 1.09) | 396 (66.9) | 0.81 (0.66 – 1.00) |
| Circumcision status (2) | |||||||
| No | 547 (31.2) | 469 (28.5) | 1.00 (Referent) | 351 (30.2) | 1.00 (Referent) | 196 (33.1) | 1.00 (Referent) |
| Before 1st sexual intercourse | 1,139 (64.9) | 1,135 (69.0) | 0.86 (0.73 – 1.01) | 764 (65.8) | 0.89 (0.75 – 1.07) | 375 (63.3) | 0.80 (0.65 – 1.00) |
| After 1st sexual intercourse | 68 (3.9) | 41 (2.5) | 1.15 (0.75 – 1.77) | 47 (4.0) | 1.26 (0.79 – 2.01) | 21 (3.6) | 0.96 (0.54 – 1.70) |
| Circumcision status (3) | |||||||
| No or after 1st intercourse | 615 (35.1) | 510 (31.0) | 1.00 (Referent) | 398 (34.3) | 1.00 (Referent) | 217 (36.7) | 1.00 (Referent) |
| Before 1st sexual intercourse | 1,139 (64.9) | 1,135 (69.0) | 0.85 (0.73 – 0.99) | 764 (65.8) | 0.88 (0.74 – 1.04) | 375 (63.3) | 0.82 (0.66 – 1.00) |
#
Disease aggressiveness based on a composite variable incorporating Gleason score, stage and PSA where more aggressive cases were defined by a Gleason score of 7(4+3) or greater, or non-localized stage, or PSA > 20 ng/mL at time of diagnosis
*
OR= odds ratio adjusted for age, race, PSA tests within the 5 years before diagnosis or reference date, family history of prostate cancer, history of any sexually transmitted infection, history of prostatitis, number of male and female sexual partners
ˆ
Same control population as for all analysis