Table 3.

Mixed Model P Values for CIPN Severity Over Time, Comparing P-APS Severity in the First Week

EORTC CIPN-20 Endpoint	Mean Decrease in CIPN Severity for P-APS Score 0–4 (versus 5–10)*	P-Value**	Mean Decrease in CIPN Severity for P-APS Score 0–4 (versus 5–10)* Using Cycles 1–4	P-Value**
Autonomic Subscale	7.8	0.007	10.2	0.003
Motor Subscale	7.9	0.004	10.4	0.0008
Sensory Subscale	11.3	0.001	14.3	0.0005
Numbness-Feet	17.0	0.001	20.4	0.002
Burning/Shooting Pain-Feet	11.5	0.02	13.7	0.02
Tingling-Feet	13.7	0.02	18.6	0.007
Numbness-Hands	16.0	0.002	20.2	0.001
Burning/Shooting Pain-Hands	8.7	0.02	10.9	0.02
Tingling-Hands	11.0	0.04	14.9	0.02

^*On a 0–100 point scale

^**Mixed modeling p values adjusted for age and race