Table 4.
Duration of vitamin or mineral supplement use and risk of head and neck cancer, INHANCE pooled analysis
| Cases / controls |
ORa (95% CI) | Cases / controls |
ORb (95% CI) | |
|---|---|---|---|---|
| Any vitamins | ||||
| None | 1601/2015 | 1.00 | 1333/1832 | 1.00 |
| <1 year | 664/1136 | 0.84(0.67-1.07) | 617/1094 | 0.84(0.60-1.16) |
| 1-9 years | 374/684 | 0.89(0.58-1.37) | 367/676 | 1.01(0.72-1.43) |
| 10+ years | 354/893 | 0.75(0.54-1.05) | 353/892 | 0.84(0.57-1.26) |
| Missing | 13/15 | 13/15 | ||
| P trend | 0.02 | 0.93 | ||
| P heterogeneity | <0.01 | <0.01 | ||
| Multiple vitamins |
||||
| None | 1453/2347 | 1.00 | 1453/2347 | 1.00 |
| <1 year | 397/688 | 0.87(0.68-1.11) | 397/688 | 0.87(0.68-1.12) |
| 1-9 years | 379/641 | 1.00(0.82-1.22) | 379/641 | 1.06(0.87-1.30) |
| 10+ years | 441/818 | 1.03(0.86-1.24) | 441/818 | 1.11(0.91-1.35) |
| Missing | 13/15 | 13/15 | ||
| P trend | 0.74 | 0.33 | ||
| P heterogeneity | 0.12 | 0.21 | ||
| Vitamin C | ||||
| None | 2193/3393 | 1.00 | 2193/3393 | 1.00 |
| <1 year | 156/355 | 0.80(0.58-1.10) | 156/355 | 0.83(0.58-1.18) |
| 1-9 years | 154/292 | 0.88(0.61-1.27) | 154/292 | 0.97(0.67-1.14) |
| 10+ years | 167/454 | 0.72(0.54-0.97) | 167/454 | 0.80(0.57-1.14) |
| Missing | 13/15 | 13/15 | ||
| P trend | 0.46 | 0.52 | ||
| P heterogeneity | <0.01 | <0.01 | ||
| Vitamin E | ||||
| None | 2297/3477 | 1.00 | 2297/3477 | 1.00 |
| <1 year | 129/359 | 0.79(0.57-1.11) | 129/359 | 0.87(0.60-1.26) |
| 1-9 years | 131/312 | 0.74(0.38-1.41) | 131/312 | 0.80(0.39-1.65) |
| 10+ years | 113/346 | 0.77(0.41-1.42) | 113/346 | 0.89(0.52-1.50) |
| Missing | 13/15 | 13/15 | ||
| P trend | 0.77 | 0.75 | ||
| P heterogeneity | <0.01 | <0.01 | ||
| Calcium | ||||
| None | 1404/2658 | 1.00 | 1404/2658 | 1.00 |
| <1 year | 56/205 | 0.72(0.48-1.07) | 56/205 | 0.71(0.47-1.07) |
| 1-9 years | 61/194 | 0.69(0.46-1.02) | 61/194 | 0.71(0.47-1.07) |
| 10+ years | 38/172 | 0.71(0.45-1.10) | 38/172 | 0.68(0.43-1.08) |
| Missing | 10/12 | 10/12 | ||
| P trend | 0.79 | 0.76 | ||
| P heterogeneity | 0.06 | 0.05 |
Odds ratio adjusted for age, sex, race/ethnicity, study center, educational level, pack-years of smoking (continuous), the frequency of alcohol drinking (continuous), vegetable and fruit intake (quartiles of center-specific controls). Any vitamins include France, North Carolina, Tampa, Los Angeles, Puerto Rico, Boston and US multicenter studies; multiple vitamins, vitamin A, vitamin C and vitamin E include North Carolina, Tampa, Los Angeles, Puerto Rico, Boston and US multicenter studies; calcium includes North Carolina, Tampa, Los Angeles, Puerto Rico and Boston studies.
Odds ratio adjusted for age, sex, race/ethnicity, study center, educational level, pack-years of smoking (continuous), the frequency of alcohol drinking (continuous), vegetable and fruit intake (quartiles of center-specific controls), and other vitamins (Multiple vitamins, vitamin A, vitamin C and vitamin E). Any vitamins, multiple vitamins, vitamin A, vitamin C and vitamin E include North Carolina, Tampa, Los Angeles, Puerto Rico, Boston and US multicenter studies; calcium includes North Carolina, Tampa, Los Angeles, Puerto Rico and Boston studies.