Table 2.
Frequency of positive responses and odds ratios for candidate items in the University of Pittsburgh Connective Tissue Disease cohort.
| Criterion | Scleroderma N = 326 |
Non-SSc comparisons | Combined Non- SSc comparisons |
ORj | |||
|---|---|---|---|---|---|---|---|
|
SLE N =113 |
PM/DM N = 118 |
SJOG N = 95 |
Raynaud’s Disease |
||||
| Abnormal nailfold capillary pattern | 18/26 (69%) | NA | 21/42 (50%) | 3/5 (60%) | 20/36 (56%) | 44/83 (53%) | 2 |
| Anti-centromere antibody | 95/313 (21%) | 2/110 (2%) | 1/82 (1%) | 2/51 (4%) | 11/84 (13%) | 16/327 (5%) | 8 |
| Anti-topoisomerase-I antibody | 63/313 (19%) | NA | 0/82 (0%) | 0/51 (0%) | 4/84 (5%) | 4/217 | 18 |
| Antinuclear antibody | 298/313 (98%) | 64/72 (89%) | 60/82 (74%) | 35/51 (69%) | 63/84 (75%) | 222/289 | 6 |
| Anti-PM-Scl antibody | 9/313 (3%) | NA | 2/82 (2%) | 0/51 (0%) | 1/84 (1%) | 3/217 | 2 |
| Anti-RNA polymerase III antibody | 81/313 (25%) | NA | 1/82 (1%) | 0/51 (0%) | 0/84 (0%) | 1/217 | 75 |
| Calcinosis | 35/241 (15%) | NA | 6/75 (8%) | 1/15 (7%) | 0/36 (0%) | 7/126 | 3 |
| Reduced DLCOa | 118/190 (62%) | 2/7 (29%) | 44/59 (75%) | 2/11 (18%) | 6/14 (43%) | 54/91 | 1 |
| Digital pulp loss or acro-osteolysisb | 12/125 (10%) | NA | 0/18 (0%) | 0/11 (0%) | 0/9 (0%) | 0/38 | NC |
| Dysphagia for solids | 139/325 (43%) | 6/106 (6%) | 23/117 (20%) | 15/95 (16%) | 14/93 (15%) | 58/411 | 10 |
| Esophageal dilationc | 106/163 (65%) | NA | 5/19 (26%) | 6/25 (24%) | 6/23 (26%) | 17/67 | 5 |
| Finger flexion contracture | 203/324 (63%) | 8/112 (7%) | 5/117 (4%) | 7/95 (7%) | 3/92 (3%) | 23/416 | 29 |
| Finger tip ulcers or pitting scars | 149/324 (46%) | 4/107 (4%) | 2/116 (2%) | 1/95 (1%) | 12/92 (13%) | 19/410 | 18 |
| Reduced FVCd | 61/204 (30%) | NA | 25/62 (40%) | 0/12 (0%) | 3/15 (20%) | 28/89 | 0.9 |
| Interstitial lung disease or pulmonary fibrosise | 106/259 (41%) | 1/50 (2%) | 40/71 (56%) | 4/46 (9%) | 2/30 (7%) | 47/197 | 2 |
| Gastro-esophageal reflux diseasef | 234/325 (72%) | 28/106 (26%) | 39/117 (33%) | 30/95 (32%) | 37/93 (40%) | 134/411 | 16 |
| Puffy fingers | 285/325 (88%) | 14/111 (13%) | 12/117 (10%) | 8/95 (8%) | 13/92 (14%) | 47/415 | 56 |
| Pulmonary arterial hypertensiong | 28/326 (9%) | 3/113 (3%) | 2/118 (2%) | 0/95 (0%) | 1/93 (1%) | 6/419 | 6 |
| Raynaud’s phenomenon | 318/326 (98%) | 67/113 (59%) | 44/117 (38%) | 42/95 (44%) | 93/93 (100%) | 246/418 | 47 |
| Renal crisis | 22/326 (7%) | 0/113 (0%) | 0/118 (0%) | 0/95 (0%) | 0/93 (0%) | 0/419 | NA |
| Scleroderma | 314/326 (96%) | 1/93 (1%) | 7/109 (6%) | 0/92 (0%) | 0/92 (0%) | 8/386 | 1190 |
| Telangiectasiash | 180/325 (55%) | 2/107 (2%) | 1/115 (1%) | 8/95 (8%) | 2/92 (2%) | 13/409 | 38 |
| Tendon or bursal friction rubsi | 95/323 (29%) | 0/75 (0%) | 0/111 (0%) | 1/91 (1%) | 0/90 (0%) | 1/367 | 153 |
NA Not Available, SLE Systemic lupus erythematosus, PM/DM Polymyositis or Dermatomyositis, SJOG Sjögren syndrome, OR Odds ratio, NE Not Estimated
Notes:
DLCO Carbon monoxide diffusion capacity, DLCO < 70% predicted
Acroosteolysis on physical examination or radiographically
Esophageal dysmotility by barium swallow or manometry
FVC Forced vital capacity; FVC < 70% predicted
Pulmonary fibrosis radiographically
Heartburn by history
Pulmonary arterial hypertension by clinical features (physical examination, echocardiogram) or right heart catheterization
Telangiectasias at any site which are believed due to connective tissue disease finger contractures recorded by the examining physician on physical exam and, separately
1 or more rubs, including the following sites; shoulders, olecranon bursae, wrists (flexor or extensors), fingers (flexor or extensor), knees, ankles (Achilles, peroneal, posterior tibial, or anterior tibial tendons)
Odds Ratios can be read as SSc patients have OR times the odds of having candidate criteria than a mimicker patient