Table 6.
Pooled odds ratios and ranking of candidate criteria.
| Criterion | Pooled mean OR (95% CrI) |
Empiric ranking |
Expert based ranking |
|---|---|---|---|
| Renal crisis | NE | 1ab | 9 |
| Digital pulp loss or acro-osteolysis | NE | 1ab | 13b |
| Scleroderma skin changes | 426.7 (256.5, 691.2) | 2 | 1 |
| Telangiectasias | 91.4 (57.6, 154.5) | 3 | 11 |
| Anti-RNA polymerase III antibody | 75.4 (13.2, 312.6) | 4 | 6 |
| Puffy fingers | 34.9 (24.0, 49.2) | 5 | 12 |
| Finger flexion contractures | 29.0 (17.8, 46.2) | 6 | 19 |
| Tendon or bursal friction rubs | 26.81 (2.4, 91.9) | 7 | 10 |
| Anti-topoisomerase-I antibody | 24.9 (12.7, 48.0) | 8 | 2 |
| Raynaud phenomenon | 24.1 (15.3, 37.5) | 9 | 7 |
| Finger tip ulcers or pitting scars | 19.3 (12.7, 28.8) | 10 | 5 |
| Anti-centromere antibody | 13.8 (9.0, 21.0) | 11 | 3 |
| Abnormal nailfold capillary pattern | 10.4 (6.9, 15.1) | 12 | 4 |
| Gastro-esophageal reflux disease | 7.6 (5.9, 9.7) | 13 | 17 |
| Antinuclear antibody | 6.06 (4.1, 8.8) | 14 | 13b |
| Calcinosis | 6.05 (3.4, 10.5) | 15 | 18 |
| Dysphagia | 5.7 (4.2, 7.7) | 16 | 19 |
| Esophageal dilation | 5.6 (2.9, 10.2) | 17 | 14 |
| Interstitial lung disease or pulmonary fibrosis | 4.5 (3.4, 5.8) | 18 | 8 |
| Anti-PM-Scl antibody | 2.4 (1.9, 7.1) | 19 | 20b |
| Pulmonary arterial hypertension | 1.2 (0.9, 1.5) | 20 | 15 |
| Reduced DLCO | 1.5 (1.1, 2.0) | 21 | 16 |
| Reduced FVC | 0.9 (0.6, 1.3) | 22 | 20b |
CrI Credible Interval, NE Not estimated, DLCO Carbon monoxide diffusion capacity, FVC Forced vital capacity
a
Renal crisis, digital pulp loss or acro-osteolysis did not occur in any mimicker patients, therefore odds ratios were not estimated. An infinitely small numeric adjustment would result in an infinitely large odds ratio.
b
Tied rankings