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The number of TLR and NLR family members varies between species. The number in parentheses for teleost TLRs reflects the paralogues identified in the Atlantic cod genome.
| TLRs | NLRs | |
|---|---|---|
| Drosophila | 9 | 0 |
| human | 10 | 22 |
| murine | 12 | 34 |
| chicken | 10 | 1 |
| teleosts | 17 (36) | NLR-A–5 |
| NLR-B–6 | ||
| NLR-C-hundreds | ||
| purple sea urchin | 222 | 203 |
| amphioxus | 71 | 118 |
