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. 2012 May;2(5):120076. doi: 10.1098/rsob.120076

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© 2012 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 3. — RhoB is required for Rac1-driven lamellipodial protrusion. (a) (i) Kymographs of representative lamellipodial regions of migrating siRNA-transfected PC3 cells from the electronic supplementary material, movie S1. Black bars denote kymograph region. Scale bars, 20 µm. (ii) Lamellipodial protrusion rate measured from five to seven cells per condition, mean ± s.d. (b) (i) Representative images and (ii) quantification of GFP-positive PC3 cells after transfection with GFP-Rac1-L61 or control GFP and the indicated siRNAs. Scale bars, 20 µm. n > 300 cells per condition from three independent experiments; boxes of box and whisker plots show median, 25th and 75th percentile; whiskers show 95th percentile; **p < 0.01, ***p < 0.001.