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. 2012 May;2(5):120076. doi: 10.1098/rsob.120076

Figure 5.

Figure 5.

RhoB and GEF-H1 affect cell morphology, but not microtubule dynamics. (a) Confocal images showing F-actin and α-tubulin distribution in PC3 cells transfected with siRNAs targeting GEF-H1, RhoA or control siRNA. Scale bars, 20 µm. (b) Graph shows quantification of cell area (mean ± s.e.m.) relative to siControl from two different experiments with >40 cells per condition; **p < 0.01. (c) Quantification of microtubule tips per unit area from movies of EB3-GFP-expressing RhoB-depleted or control cells. Graph shows mean ± s.e.m. from 10 cells in two different experiments.