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Clock-gene mediated regulation of SGLT1. Per1 exhibits circadian rhythmicity in rat jejunum and is phase-shifted similarly upon restricted feeding. Knockdown of PER1 upregulates SGLT1 expression in Caco-2 cells while reporter assays demonstrate suppression of SGLT1 expression by PER1. E-boxes also suppress SGLT1 expression independent of PER1 and possibly by other transcription factors such as other clock-controlled genes.
