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. Author manuscript; available in PMC: 2013 Apr 13.
Published in final edited form as: Circ Res. 2012 Apr 13;110(8):1139–1150. doi: 10.1161/CIRCRESAHA.111.246470

Figure 2.

Figure 2

A simplified model representing the effect of nutrients and IGF-I on cellular protection and the differences between the intracellular signaling cascades triggered by the circulating IGF-I and the cardiomyocyte-produced mIGF-I isoform. Because studies on the effect and role of the mIGF-I isoform are relatively new, the right panel represents only a potential model for mIGF-I effects on cardioprotection. Additional studies are necessary to confirm this role. Question marks indicate mechanisms not fully clarified. Dashed lines indicate hypothetical interactions. See text for details and references. (Illustration credit: Cosmocyte/Ben Smith).