Figure 3. MAs in lung tissue are a diagnostic marker for TB infection in mice.

MAs were extracted from homogenized lungs of MTB-infected mice, spiked with synthetic C32 MA standard and the most abundant mycobacterial MA species were quantified using MRM.

1. Levels of individual MA molecular species in the lung of one infected, untreated mouse 5 weeks post-infection.
2. MA levels of non-infected control mice compared to MTB-infected and to rifampicin-treated mice. The average bacillary load in this infections was 15.2 million CFU/lung (n = 5).