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. Author manuscript; available in PMC: 2013 Jul 15.
Published in final edited form as: Bioorg Med Chem Lett. 2012 May 17;22(14):4854–4858. doi: 10.1016/j.bmcl.2012.05.038

Table 1.

IC50s (μM) against human prostate cancers after 24, 48, and 72 h exposure to haloenol inhibitorsa

compd LNCaP PC-3

24 48 72 24 48 72
rac-BEL 13 5 9 34 26 14
2a 10 5 5 19 23 14
2b 9 5 7 32 15 16
rac-4 31 5 4 27 10 6
(S)-14a 8 3 3 15 13 5
(R)-14b 6 6 3 8 6 3
(S)-15 26 23 20 21 21 25
(S)-16 41 26 32 33 57 39
17 25 29 28 13 10 7
(S)-20 3 4 3 4 1 4
a

Data represent the calculated IC50 using data assessed 3–5 experiments ran in duplicate using separate passages of cells assessing alteration in MTT staining.