Table 3.
Hazard ratios of endometrial cancer in quartiles of lipoprotein components and ratios, adjusted for age, parity, glucose (continuous), triglycerides (continuous), total cholesterol (continuous), fasting status, and SES.
| N(%) | Hazard Ratio (95% CI) | ||
|---|---|---|---|
| Endometrial Cancer | No Endometrial Cancer | ||
| Triglycerides (mmol/L)1 | |||
| <0.70 | 148 (12.94) | 53155 (23.70) | 1.00 (Ref) |
| 0.70-0.90 | 183 (16.00) | 47176 (21.03) | 1.10 (0.88-1.37) |
| 0.90-1.30 | 339 (29.63) | 61508 (27.42) | 1.34 (1.09-1.63) |
| ≥1.30 | 474 (41.43) | 62449 (27.84) | 1.57 (1.28-1.92) |
| P-value for trend | <0.001 | ||
| Total cholesterol (mmol/L)2 | |||
| <4.80 | 122 (10.66) | 56221(25.07) | 1.00 (Ref) |
| 4.80-5.50 | 223 (19.49) | 54931 (24.49) | 1.28 (1.02-1.60) |
| 5.50-6.30 | 324 (28.32) | 55272 (24.64) | 1.28 (1.03-1.59) |
| ≥6.30 | 475 (41.52) | 57864 (25.80) | 1.15 (0.93-1.43) |
| P-value for trend | 0.731 | ||
| LDL-cholesterol (mmol/L)b,2 | |||
| <2.70 | 19 (11.45) | 7726 (23.78) | 1.00 (Ref) |
| 2.70-3.36 | 41 (24.70) | 8152 (25.09) | 1.48 (0.85-2.56) |
| 3.36-4.13 | 42 (25.30) | 8204 (25.25) | 1.11 (0.64-1.94) |
| ≥4.13 | 64 (38.55) | 8411 (25.89) | 1.16 (0.67-2.00) |
| P-value for trend | 0.857 | ||
| HDL-cholesterol (mmol/L) b,2 | |||
| <1.45 | 49 (29.52) | 8345 (25.68) | 1.00 (Ref) |
| 1.45-1.70 | 42 (25.30) | 8240 (25.23) | 1.03 (0.66-1.60) |
| 1.70-1.98 | 29 (17.47) | 7983 (24.57) | 0.72 (0.44-1.19) |
| ≥1.98 | 46 (27.71) | 7925 (24.39) | 0.97 (0.62-1.54) |
| P-value for trend | 0.645 | ||
| Apolipoprotein B (g/L)b | |||
| <0.93 | 19 (11.46) | 8071 (24.84) | 1.00 (Ref) |
| 0.93-1.11 | 34 (20.48) | 8063 (24.81) | 1.06 (0.60-1.89) |
| 1.11-1.34 | 41 (24.70) | 7841 (24.13) | 0.90 (0.49-1.65) |
| ≥1.34 | 72 (43.37) | 8518 (26.21) | 1.01 (0.50-2.03) |
| P-value for trend | 0.885 | ||
| Apolipoprotein A-I (g/L)b | |||
| <1.35 | 37 (22.29) | 8434 (25.96) | 1.00 (Ref) |
| 1.35-1.49 | 46 (27.71) | 8128 (25.01) | 1.14 (0.74-1.77) |
| 1.49-1.65 | 36 (21.69) | 7706 (26.72) | 0.89 (0.56-1.42) |
| ≥1.65 | 47 (28.31) | 8225 (25.31) | 0.96 (0.61-1.51) |
| P-value for trend | 0.606 | ||
| Total Cholesterol/HDL ratio b,2 | |||
| <2.69 | 30 (18.07) | 7758 (23.88) | 1.00 (Ref) |
| 2.69-3.22 | 34 (20.48) | 7951 (24.47) | 0.93 (0.56-1.52) |
| 3.22-3.98 | 40 (24.10) | 8276 (25.34) | 0.85 (0.52-1.39) |
| ≥3.98 | 62 (37.35) | 8508 (26.18) | 0.88 (0.53-1.47) |
| P-value for trend | 0.605 | ||
| LDL/HDL ratiob,2 | |||
| <1.52 | 33 (19.88) | 8210 (25.27) | 1.00 (Ref) |
| 1.52-2.00 | 31 (18.67) | 8053 (24.78) | 0.80 (0.49-1.31) |
| 2.00-2.66 | 47 (28.31) | 8161 (25.12) | 0.97 (0.61-1.53) |
| ≥2.66 | 55 (33.13) | 8069 (24.88) | 0.81 (0.50-1.31) |
| P-value for trend | 0.564 | ||
| ApoB/apoA-I ratiob | |||
| <0.60 | 26 (15.66) | 7988 (24.58) | 1.00 (Ref) |
| 0.60-0.75 | 38 (22.89) | 8431 (25.95) | 1.02 (0.62-1.68) |
| 0.75-0.93 | 40 (24.10) | 7830 (24.10) | 0.86 (0.52-1.43) |
| ≥0.93 | 62 (37.35) | 8244 (25.37) | 0.93 (0.56-1.54) |
| P-value for trend | 0.657 | ||
| Triglycerides/HDL ratiob,2 | |||
| <0.37 | 28 (16.87) | 8359 (25.73) | 1.00 (Ref) |
| 0.37-0.54 | 34 (20.48) | 7941 (24.44) | 1.18 (0.71-1.95) |
| 0.54-0.87 | 44 (26.51) | 8124 (25.00) | 1.38 (0.86-2.24) |
| ≥0.87 | 60 (36.14) | 8069 (24.83) | 1.67 (1.05-2.66) |
| P-value for trend | 0.021 | ||
1
Not adjusted for TG;
2
Not adjusted for TC;
b
Measured in subgroup B