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. 2011 Aug;3(8):438–450. doi: 10.1002/emmm.201100157

Figure 1. The complexity of the genetics underlying ASD.

Figure 1

Figure 1

  1. Ideogram showing the relative locations of genes implicated in ASD susceptibility, adapted from the UCSC Genome Browser (http://genome.ucsc.edu/). Genes in black are listed as ‘known ASD genes’ in Pinto et al (2010) Supporting information Table 9. Genes in green are listed as ‘ASD candidates’ in Pinto et al (2010) Supporting information Table 9. Genes in blue are additional genes reported as showing association with ASD (Sousa et al, 2011, Table 2.1).
  2. Network of known and predicted interactions between proteins encoded by genes implicated in ASD susceptibility produced by the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) 9.0 (http://string.embl.de/) using default settings. Proteins are represented by spheres, the colours corresponding to the genes in (A) (protein names may differ from gene names, for example, SHANK3 encodes PSAP2). Lines linking proteins indicate evidence for interactions; pale green = textmining, light blue = databases, pink = experimental, pale purple = homology, black = co-expression, bright green = neighbourhood (the genes reside within 300 bp on the same strand in the genome).