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. 2011 Sep;3(9):545–558. doi: 10.1002/emmm.201100158

Figure 6. QC/isoQC-inhibition alleviates atherosclerotic pathology in a model of cuff-induced accelerated atherosclerosis.

Figure 6

  1. Monocyte adhesion and total adhering cells 2 days after cuff placement in absence (black bars) or presence (open bars) of PQ50 (QCI) treatment (*p < 0.05 vs. control, Student's t-test, n = 5, mean ± SD).
  2. In addition, the CCL2-positive area was calculated in cross-sections within the media and neointima in absence (black bars) and presence (open bars) of PQ50 (QCI) treatment (**p < 0.01, ***p < 0.001 vs. control. Student's t-test, n = 5, mean ± SD).
  3. Morphometric analysis of cuffed vessel segments shows a reduction in the degree of lumen stenosis (*p < 0.05 vs. control, Student's t-test, n = 10, mean ± SD). Inset: Example for lumen stenosis after 2 weeks (black arrows).
  4. Neointima formation and media thickness (inset) of the cuffed vessel segments of mice sacrificed after 2 weeks, treated in absence (black bars) and presence (open bars) of QC-inhibitor PQ50 (QCI; *p < 0.05 vs. control, Student's t-test, n = 10, mean ± SD).