Table 1.

Experimental examples of oncogene addiction

Oncogene	Models
	In vitro	In vivo	References
MYC	RNAi in haematopoietic cells	Conditional MYC-driven mouse models of leukaemia	Felsher and Bishop (1999), Loke et al (1988)
H-RAS, K-RAS	Farnesyl transferase inhibitors in H-RAS-transformed and K-RASmut expressing cell lines	Conditional K-RASmut-driven mouse model of lung cancer	Fisher et al (2001), Kohl et al (1994)
ABL	Small-molecule inhibitor in BCR-ABL expressing cell lines	Systemic antisense oligodeoxynucleotides delivery in mouse model of CML	Druker et al (1996), Skorski et al (1994)
HER2	RNAi in erbB-2 amplified breast carcinoma cell lines	Conditional erbB-2-driven mouse model of mammary cancer	Colomer et al (1994), Moody et al (2002)
EGFR	Ribozyme against aberrant EGFR-expressing cell line	mAB in EGFR-amplified xenografts	Luwor et al (2001), Yamazaki et al (1998)

RNAi, RNA interference; mAB, monoclonal antibody.