Table 1.
Oncogene | Models | ||
---|---|---|---|
In vitro | In vivo | References | |
MYC | RNAi in haematopoietic cells | Conditional MYC-driven mouse models of leukaemia | Felsher and Bishop (1999), Loke et al (1988) |
H-RAS, K-RAS | Farnesyl transferase inhibitors in H-RAS-transformed and K-RASmut expressing cell lines | Conditional K-RASmut-driven mouse model of lung cancer | Fisher et al (2001), Kohl et al (1994) |
ABL | Small-molecule inhibitor in BCR-ABL expressing cell lines | Systemic antisense oligodeoxynucleotides delivery in mouse model of CML | Druker et al (1996), Skorski et al (1994) |
HER2 | RNAi in erbB-2 amplified breast carcinoma cell lines | Conditional erbB-2-driven mouse model of mammary cancer | Colomer et al (1994), Moody et al (2002) |
EGFR | Ribozyme against aberrant EGFR-expressing cell line | mAB in EGFR-amplified xenografts | Luwor et al (2001), Yamazaki et al (1998) |
RNAi, RNA interference; mAB, monoclonal antibody.