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. 2011 Nov;3(11):637–651. doi: 10.1002/emmm.201100172

Figure 5. Loss of RORγ protects against diet-induced insulin resistance in mice.

Figure 5

  • A. Body weight of Rorγ−/− and wild-type mice (12 weeks) crossed into the ob/ob background or fed a high-fat diet (DIO) for 8 weeks (n = 7–10).
  • B,C. Fasting blood glucose and serum insulin of ob/ob and high-fat diet Rorγ−/− and wild-type mice (n = 7–10).
  • D. Insulin tolerance test with male Rorγ−/− and wild-type mice after 8 weeks of high-fat diet injected intraperitoneal (i.p.) with 0.75 U/kg insulin (n = 7).
  • E. In vitro lipolysis of isolated adipocytes from 12-week-old wild-type mice on a chow diet, ob/ob wild-type and ob/ob Rorγ−/− mice treated with or without insulin normalized to cell number and set to 100% for basal lipolysis (n = 4).
  • F. Fasting free fatty acid serum concentrations of ob/ob and high-fat diet Rorγ−/− and wild-type mice (n = 7–10).
  • G. Expression of Rorγ, Mmp3 and A-Fabp in visceral adipose tissue of male C57Bl/6 mice during a time course of high-fat diet feeding. Body weight and mean adipocyte size of the animals was monitored.