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. 2010 Jan;2(1):6–15. doi: 10.1002/emmm.200900053

Figure 3. SATB1 organizes the genome for coordinate gene regulation.

Figure 3

SATB1 forms a network that overlaps the base of chromatin loops and has been shown to recruit chromatin modifying complexes. SATB1 interacts with C-terminal binding protein 1 (CtBP1), histone deacetylase 1 (HDAC1), p300/CBP-associated factor (PCAF) and cut-like 1 (CUTL1) and colocalizes with GATA binding protein 3 (GATA3). The current view is that spatial and molecular organization of the genome is modulated by SATB1, which might be important for establishing epigenetic patterns and for coordinating gene expression.