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. 2010 Feb;2(2):42–50. doi: 10.1002/emmm.200900057

Figure 2. Distribution of myelin and axonal pathology along the optic pathway of Plp1-transgenic mice aged P120.

Figure 2

  • A. Retinal end of optic nerve: all myelin has been removed leaving naked axons, which appear morphologically normal and are interspersed with astrocyte processes. Bar: 1 µm.
  • B, C. Chiasmal end of optic nerve: demyelination is on-going although most axons have lost their sheaths. Microglia (M) and axonal spheroids (S) are present. Bar: 2 µm.
  • D. Optic tract: demyelination is present but not as advanced as at the chiasm. Microglia and axonal spheroids are evident. Bar: 3 µm.