Figure 6. Relatively few sites of axonal transport stasis are associated with diffuse, low level inflammation.

1. Longitudinal sections of optic nerve (retinal end left) from the dysmyelinating rumpshaker mouse aged P40, immunostained for CD45 and CD169 (sialoadhesin). There is no gradient in the distribution of microglia/macrophages along the optic nerve and activated, sialoadhesin positive cells are present in low numbers compared to the P120 Plp1-transgenic nerve.
2. Eighteen hours after injection of CtB into the rostral colliculus of P40 rumpshaker mouse, a relatively small number of CtB positive foci are present at similar densities in retinal and chiasmal portions of the nerve.