Table 1.
Fatty acid levels in Elo3p mutant yeast transformed with human ELOVL proteins and yeast Elo3p
| ELOVL1 | ELOVL3 | ELOVL4 | ELOVL5 | ELOVL6 | ScELO3 | |
|---|---|---|---|---|---|---|
| C18:1 | — | — | — | 170%** | 170%*** | — |
| C20:1 | — | — | — | 380%*** | — | — |
| C22:1 | — | 340%*** | — | 220%* | — | — |
| C24:1 | 810%*** | >1000%*** | — | — | — | — |
| C26:1 | 830%*** | — | — | — | — | >1000%*** |
| C16:0 | — | — | — | — | 51%*** | — |
| C18:0 | — | — | — | — | 160%** | — |
| C20:0 | — | — | — | — | 160%* | 20%* |
| C22:0 | 45%** | — | 140%* | — | — | 15%*** |
| C24:0 | >1000%*** | — | — | — | — | — |
| C26:0 | >1000%*** | — | — | — | — | >1000%*** |
| C28:0 | — | — | — | — | — | >1000%** |
Data are presented only for those transformants for which the ANOVA p-value was <0.05. No significant changes were observed in transformants expressing either ELOVL2 or ELOVL7. For each elongase, at least three independent clones were analysed. Results are expressed as percentage relative to the amount measured in BY4742Δelo3 yeast. *p < 0.05, **p < 0.01 and ***p < 0.001 by ANOVA followed by Dunnett's multiple comparison test compared with BY4742Δelo3.