Skip to main content
. 2010 Jun;2(6):211–230. doi: 10.1002/emmm.201000073

Figure 5. Oxidative stress-mediated HIF-1α accumulation promotes myofibroblast properties.

Figure 5

  1. Representative immunofluorescence of myofibroblast markers in junD−/− fibroblasts after transfection with a scramble siRNA (si control) (a,c,e,g) or with an HIF-1α-directed siRNA (si HIF) (b,d,f,h).
  2. Representative immunofluorescence of myofibroblast markers in wt fibroblasts either untreated (a,c,e,g) or incubated with DFO (b,d,f,h).
  3. Representative GST pull-down assays for RhoA (left panel) and Rac (right panel) on wt fibroblasts with or without DFO.
  4. Representative immunofluorescence of myofibroblast markers in junD−/− fibroblasts either untreated (a,c,e,g) or incubated with NAC (b,d,f,h). Scale bars = 10 µm.