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. 2010 Jun;2(6):211–230. doi: 10.1002/emmm.201000073

Figure 7. HER2 tumours exhibit high content of myofibroblasts and display a stress response signature.

Figure 7

  1. Representative staining of SM-α-actin in HER2 (a–c), BLC (d–f) and Lum-A (g–i) human breast tumours. Arrowheads indicate SM-α-actin staining in epithelial cells in BLC (f). p-values are as in Fig 6.
  2. Representative graph of the percentage of fibroblasts compared to total cells forming the tumour in each breast cancer subtype. p-values by χ2 test are highly significant between BLC and HER2 or Lum-A (≤0.001) and non-significant between HER2 and Lum-A.
  3. Gene Ontology pathways significantly at least 2-fold up-regulated in HER2 versus Lum-A, BLC versus Lum-A and HER2 versus BLC, as indicated. p-values by Fisher Exact test adjusted using the Benjamini–Hochberg correction are indicated.