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. 2010 Dec;2(12):504–515. doi: 10.1002/emmm.201000103

Figure 5. Chemistry optimization and IC50s of ASK1 inhibitor.

Figure 5

  1. Medicinal chemistry optimization led to the identification of the compound MSC2032964A.
  2. MSC2032964A showed IC50 values below 10 µM for only two kinases: ASK1 and CK1δ, at 93 and 4800 nM, respectively.