Table 3.
Odds of Preterm Birth by Quartile of LINE-1 DNA Methylation among 1160a Participants Enrolled in Project Viva
| Preterm Cases | Unadjusted | Adjustedb | |
|---|---|---|---|
| n (%) | OR (95% CI) | ||
| First Trimester | |||
| 1st quartile | 19 (8.3) | 1.0 (reference) | 1.0 (reference) |
| 2nd quartile | 17 (7.4) | 0.88 (0.45, 1.74) | 0.91 (0.45, 1.81) |
| 3rd quartile | 14 (6.1) | 0.72 (0.35, 1.47) | 0.72 (0.35, 1.49) |
| 4th quartile | 8 (3.5) | 0.40 (0.17, 0.93) | 0.40 (0.17, 0.94) |
| Second Trimester | |||
| 1st quartile | 15 (6.5) | 1.0 (reference) | 1.0 (reference) |
| 2nd quartile | 12 (5.2) | 0.79 (0.36, 1.72) | 0.79 (0.36, 1.75) |
| 3rd quartile | 17 (7.4) | 1.14 (0.55, 2.34) | 1.14 (0.55, 2.37) |
| 4th quartile | 17 (7.4) | 1.14 (0.56, 2.35) | 1.16 (0.56, 2.40) |
| Cord Blood (sex-specific quartiles) | |||
| 1st quartile | 3 (2.2) | 1.0 (reference) | 1.0 (reference) |
| 2nd quartile | 6 (4.3) | 2.01 (0.49, 8.22) | 2.14 (0.50, 9.08) |
| 3rd quartile | 7 (5.0) | 2.37 (0.60, 9.35) | 2.29 (0.55, 9.48) |
| 4th quartile | 11 (7.9) | 3.87 (1.05, 14.2) | 4.55 (1.18, 17.5) |
a
First trimester n=914 (unadjusted) & n=884 (adjusted); second trimester n=922 (unadjusted) & n= 893 (adjusted); cord blood n=557 (unadjusted) & n= 534 (adjusted) because of missing data.
b
Adjusted for maternal age, BMI, race/ethnicity, education, smoking and infant sex in multivariable logistic regression models
LINE-1, long interspersed nuclear element-1, %5mC, %5-methylated cytosines