Table 4: Treatment Comparisons of UVB Phototherapy and UVA Photochemotherapy for Moderate-To-Severe Plaque Psoriasis.
| Study | Comparison of Clinical Outcomes by Type of Ultraviolet Irradiation | |||
|---|---|---|---|---|
| Gordon et al., (90) 1999; N = 100 | NB-UVB vs. Oral-PUVA | |||
| Treat Till Clear | Clearance (no psoriasis) |
Mean Number of Treatments to Clearance |
Mean Cumulative UV Dose (J/cm2) to Clearance |
Remission At 6 Months Randomized/Cleared |
| NB-UVB (2x wkly) | 32/51 (63%) | 25.3 | 35 | 12% / 22% |
| Oral-PUVA (2x wkly) | 41/49 (84%) | 16.7 | 70.1 | 35% / 41% |
| OR = 3.04 (1.18,7.84); p = .018 | p < .001 | p < .001 | p = .002 | |
| Markham et al., (91) 2003; N = 54 | NB-UVB vs. Oral-PUVA | |||
| Treat Till Clear | Complete clearance | Mean Number of Treatments to Clearance (95% CI) | Mean Cumulative UV Dose (J/cm2) to Clearance | Mean Number Days in Remission (95% CI) |
| NB-UVB (3x wkly) | NR | 25.5 (18.0, 32.5) | NR | 288.5 (170.6,365) |
|
Oral-PUVA (2x wkly) |
NR |
19 (14.6, 25.8) |
NR |
231 (162.7,365) |
| p = .03 | NSD | |||
| Yones et al., (92) 2006; N = 88 | NB-UVB + Placebo vs. Oral-PUVA | |||
| 15 weeks treatment (30 Treatments) | Clearance (PGA C/AC) [Median PASI, pre→post at 8 sessions] | Mean Number of Treatments to Clearance | Mean Cumulative UV Dose (J/cm2) | Remission at 6 months (Median time to relapse) |
| NB-UVB + Oral placebo (2x wkly) | 31/37 (84%) [9.6 → 5.7] | 28.5 | 41.3 | 23/34 (68%) (8 months) |
|
Oral-PUVA (2x wkly) |
22/34 (65%) [11.0 → 4.2] |
17.0 |
126 |
8/23 (35%) (4 months) |
|
p = .02, p = 001 |
p < .001 |
p < .001 |
p = .03 |
|
| Grundman-Kollman et al. (76) 2004; N = 30 | NB-UVB + Cream-PUVA vs. Cream-PUVA vs. NB-UVB | |||
| Treat Till Clear | Clearance Time (range) to Complete Clearance |
Mean Number of Treatments to Clearance ± SD (range) | Mean Cumulative UV (J/cm2) A and UVB (J/cm2) Dose to Clearance ± SD (range) | Remission |
| NB-UVB + Cream-PUVA (4x wkly) | 10/10 (3– 4 wks) | 14 ± 2 (12 – 16) | UVA: 18.7 ± 4.7 (13.2 – 28) UVB: 8.2 ± 3.3 (4.0 – 15.4) |
NR |
|
Cream-PUVA (4x wkly) |
10/10 (5–7 wks) |
24 ± 5 (18 – 33) |
45.0 ± 16.3 (26.2 – 80.5) |
NR |
|
NB-UVB (4x wkly) |
10/10 (5–7 wks) |
21 ± 3 (15 – 25) |
17.1 ± 4.1 (12.7 – 24) |
NR |
| NSD | p < .001 | p < .001 | ||
| Khurshid et al., (93) 2000; N= 44 |
Oral-PUVB vs. Oral-PUVA |
|||
| 7 week treatment (21 sessions) + 10 wk maintenance | Clearance (90% reduction) | Mean Number of exposures to clearance | Mean Cumulative UV Dose (J/cm2) to Clearance | Remission |
| Oral-PUVB (3x wkly) | 17/22 (77.3%) | 18 | 25.2 | NR |
|
Oral-PUVA (3x wkly) |
19/22 (86.4%) |
16 |
72.5 |
NR |
| NSD | NSD | p < .001 | ||
NR Not reported NSD Not statistically different