Table 11: GRADE Quality of Evidence for the Accuracy of Magnetic Resonance Imaging Plus Mammography in the Screening of Women at High Risk for Breast Cancer.
| Outcome | Explanation | GRADE |
|---|---|---|
| Design | 11 non-randomize clinical trials (observational studies) | High |
| Quality | All subjects exposed to both MRI and FMand CA; heterogeneity in both summary estimates of sensitivity and specificity | High → Moderate |
| Consistency | Consistent for sensitivity and specificity | Unchanged |
| Directness | Direct comparisons of MRI plus FM to either MRI or FM alone. | Unchanged |
| Quality of evidence | Moderate |