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. 2010 Mar 1;10(3):1–55.
Studies Included Comments Conclusions*
5 studies, all restricted to women at high genetic risk.
  • Evidence on long-term clinical outcomes not available.

  • Hence, sensitivity and specificity are limited outcome measures.

  • MRI screening of women at high risk is recommended.

  • High-risk is defined as confirmed presence of BRCA1/2 mutation, or known mutation in relatives, or multiple affected 1st degree relatives, often at young ages and with bilateral disease.

*

BRCA1/2 indicates the presence of either a BRCA1 and/or BRCA2 gene mutation.