Table 6: Description of RCTs comparing MAS to CPAP for the treatment of OSA.
| Study | Inclusion criteria | N (# males) |
Mean age |
Mean BMI |
Duration of study (wash out period) |
|---|---|---|---|---|---|
| Hoekema et al. 2008 (16-19)* |
AHI >5 | 103 | 48.8 (SD 9.5) |
32.3 (SD 6.1) |
8 weeks (NA) |
| Parallel arm study | |||||
| Lam et al. 2007 (20) |
AHI 5-40 ESS >9 for pts with AHI 5−20 |
101 (79) | 47.0 (SD 20.0) |
27.3 (SD 6.0) |
10 weeks (NA) |
| Parallel arm study | |||||
| Barnes et al. 2004 (10) |
Adequate dentition AHI 5−30 |
114 (91) | 47.0 (SD 9.6) |
31.1 (SD 5.3) |
3 months (2 weeks) |
| Crossover study | |||||
| Engleman et al. 2002 (21) |
AHI>5 and 2 or more OSA symptoms Adequate dentition |
51 (39) | 46 (SD 9) |
NR | 8 weeks (NR) |
| Crossover study | No patients working shift work | ||||
| Randerath et al. 2002 (22) |
AHI 5−30/h (mild to moderate) Clinical symptoms of OSA |
20 (16) | 56.5 (SD 10.2) |
31.2 (SD 6.4) |
6 weeks (NR) |
| Crossover study | |||||
| Tan et al. 2002 (23) |
AHI <50 (mild-moderate) >18 years Adequate dentition |
27 (20) (3 drop outs) |
50.9 (SD 10.1) |
31.9 (SD 6.8) |
2 months (2 weeks) |
| Crossover study | |||||
| Ferguson et al. 1997 (24) |
Symptomatic mild-moderate OSA (AHI 15-55/h) At least 10 teeth in maxillary |
24 (19) (4 dropouts) |
44 (SD 10.6) |
32.0 (SD 8.2) |
4 months (2 weeks) |
| Crossover study | and mandibular arches | ||||
| Ferguson et al. 1996 (25) |
Symptomatic mild-moderate OSA (AHI 15−50/h) |
27 (24) (2 dropouts) |
46.2 (SD 10.9) |
30.4 (SD 4.8) |
4 months (2 weeks) |
| Crossover study | |||||
Note: CPAP, continous positive airway pressure; OSA, obstructive sleep apnea SD, standard deviation; SEM, standard error of the mean; SF-36, short form health survey
*
The same group of authors published results for a RCT between 2007-2008.