Table 7: AHI reported in RCTs comparing MAS to CPAP for the treatment of OSA.
| Study | Treatment | Baseline AHI (h) |
Follow-up AHI (h) |
Mean difference between baseline and follow-up |
Mean difference between MAS and Placebo |
Clinical significance |
|---|---|---|---|---|---|---|
| Hoekema et al. 2008 (16-19)* |
MAS (n=51) | 39.4 SD 30.8 | 7.8 SD 14.4 | 31.6 NR |
5.4 P=.006 |
Yes |
| Parallel arm study (N=103) |
CPAP (n=52) |
40.3 SD 27.6 | 2.4 SD 4.2 | 37.9 NR |
Yes | |
| Lam et al. 2007 (20) |
MAS (n=34) | 20.9 SD 14.0 | 10.6 SD 14.0 | 10.6 P <.001 |
7.8 P<.05 |
Borderline |
| Parallel arm study (N=101) |
CPAP (n=34) |
23.8 SD 15.7 | 2.8 SD 9.1 | 21.0 P <.001 |
Yes | |
| Barnes et al. 2004 (10) |
MAS | 21.3 SD 11.6 | 14.0 SD 9.8 | 7.3 P <.001 |
9.2 P <.05 |
No |
| Crossover study (N=80) |
CPAP | 21.3 SD 11.6 | 4.8 SD 4.5 | 16.5 P <.001 |
Yes | |
| Engleman et al. 2002 (21) |
MAS | 30 SD 21 | 15 SD 16 | 15.0 NR |
7.0 P<.001 |
Yes |
| Crossover study (N=48) |
CPAP | 32 SD 29 | 8 SD 6 | 24.0 NR |
Yes | |
| Randerath et al. 2002 (22) |
MAS | 17.5 SD 7.7 | 13.8 SD 11.1 | 3.7 P <.05 |
10.6 P <.01 |
No |
| Crossover study (N=20) |
CPAP | 17.5 SD 7.7 | 3.2 SD 2.9 | 14.3 P <.01 |
Yes | |
| Tan et al. 2002 (23) |
MAS | 22.2 SD 9.6 | 8.0 SD 4.1 | 14.2 P <.001 |
4.9 P=NS |
Yes |
| Crossover study (N=24) |
CPAP | 22.2 SD 9.6 | 3.1 SD 2.8 | 19.1 P <.001 |
Yes | |
| Ferguson et al. 1997 (24) |
MAS | 25.3 SD 15.0 | 14.2 SD 14.7 | 11.1 P <.005 |
10.2 P <.01 |
No |
| Crossover study (N=24) |
CPAP | 23.5 SD 16.5 | 4.0 SD 2.2 | 19.5 P <.005 |
Yes | |
| Ferguson et al. 1996 (25) |
MAS | 19.7 SD 13.8 | 9.7 SD 7.3 | 10.0 P <.005 |
6.1 NR |
Yes |
| Crossover study (N=27) |
CPAP | 17.6 SD 13.2 | 3.6 SD 1.7 | 14.0 P <.005 |
Yes |
Note: AHI, apnea hypopnea index; CPAP, continuous positive airway pressure; MAS, mandibular advancement splint; NR, not reported; SD, standard deviation
*
The same group of authors published results for a RCT between 2007-2008.