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. 2009 Sep 1;9(5):1–51.

Table 13: Adverse events reported in RCTs comparing MAS to placebo or CPAP for the treatment of OSA.

Adverse events
Study MAS Placebo
Petri, 2008 (8)

  • Intolerant (2 pts)

  • TMJ pain (1 pt)

  • Loosening teeth (1 pt)

  • Intolerant (1 pt)

  • Loosening teeth (1 pt)
Blanco, 2005 (9)

  • Excessive salivation (2 pts)
Gotsopoulos, 2004 (11-13)

  • Jaw discomfort

  • Tooth tenderness

  • Excessive salivation
Johnston, 2002 (14)

  • Excessive salivation (68%)

  • Temporary occlusal changes (10%)

  • TMJ discomfort upon waking (42%)
Mehta, 2001 (15)

  • Excessive salivation (50%)

  • Gum irritation (20%)

  • Mouth dryness (46%)

  • Jaw discomfort (13%)

  • All events were mild to moderate
Study MAS CPAP
Lam et al. 2007 (20)

  • Excessive salivation (56%)

  • TMJ discomfort (38%)

  • Dryness in throat (33%)

  • Tooth discomfort (33%)

  • Dryness of the nose, mouth or throat (47%)

  • Pressure on face (32%)

  • Noise from machine (24%)

  • Facial skin abrasion (21%)
Engleman et al. 2002 (21)

  • Pain in teeth, gums or jaw (69%)

  • MAS moves in sleep (40%)

  • Sleep disruption (25%)

  • Excessive salivation (19%)

  • Dental crown damaged (6%)

  • Sleep disruption (33%)

  • Leaky or painful mask (23%)

  • Stuffy nose (17%)

  • Mask moves in sleep (15%)

  • Cold airstream (15%)

  • Noise/inconvenience (13%)

  • Dry upper airway (10%)
Randerath et al. 2002 (22)

  • Pressure in mouth (2 pts)

  • Non-persisting discomfort in mouth and TMJ (8 pts)

  • Pressure on face (8 pts)
Tan et al. 2002 (23)

  • 50% jaw discomfort upon waking

  • Nasal stuffiness (mild)
Ferguson et al. 1997 (24)

  • None had severe side effects

  • 15% severe side effects
Ferguson et al. 1996 (25)

  • 6/25 pts could not tolerate MAS to complete study

  • Side effects were reported as severe in 1 patient, and moderate in 5

  • Side effects were reported as severe in 4 patients, and moderate in 5.