Table 6: Summary of Randomized Controlled Trial by Graff et al. 2006, 2007 (35;36).

Study/ Year	Population	Description of Intervention	Outcome/ Follow-Up	Results	Limitations
Graff et al.(35) 2006 Graff et al. (36) 2007	N=135 Mild to moderate dementia	Intervention: 10 1-hour sessions of occupational therapy (OT) over 5 weeks (including cognitive and behavioural interventions) Total time: 18 hrs per patient and CG together Control: no OT	CG burden Patients’ daily functioning assessment (determined by assessment of motor and process skills [AMPS] and interview of deterioration in daily activities in dementia [IDDD])	CGs: At 6 wks CGs who received OT felt significantly more competent than those who did not Mean competence score (assessed by sense of competence questionnaire [SCQ]) Difference at 6 weeks 11.0 (9.2–12.8) statistically and clinically significant Number needed to treat: 2.5 (2.3–2.7)	Generalizability of results, due to recruitment of patients from a memory clinic and day clinic of a university hospital. Short study duration (12 weeks). Unclear if controls were on wait-list. Intervention was directed at patients and CGs – unclear.
			Baseline, 6 weeks, and 3 months	Outcomes remained at 12 weeks	In 18% of cases (n=21) the assessors knew the treatment allocation.
			Outcomes(36) CG: QOL Health status Mood Control over life (mastery)	Patient: At 6 weeks, patients in the OT group significantly improved in daily functioning and outcomes remained significant at 3 months
				Results(36) At 6 weeks, CGs in the OT group had significantly improved outcomes for overall quality of life, health status, depression, and mastery than those in the control group (P < .0001). Outcomes remained significant at 3 months.

^*CG indicates caregiver; QOL, quality of life.