Table A1: GRADE table for EGFR mutation testing in the first-line setting.

Studies	Quality Assessment					Summary
	Design	Quality	Consistency	Directness	Other Modifying Factors	Overall Quality
Mok, 2009 Lee, 2009 Maemondo, 2010, Mitsudomi, 2010	Observational, prospective	None	None	None	None	MODERATE
	MODERATE	MODERATE	MODERATE	MODERATE	MODERATE