Table 4: Body of evidence examined according to study design.
| Study Design |
Number of Eligible Studies |
|---|---|
| RCT Studies | |
| Systematic review of RCTs | |
| Large RCT | |
| Small RCT | |
| Observational Studies | |
| Systematic review of non-RCTs with contemporaneous controls | |
| Non-RCT with contemporaneous controls | 14 |
| Systematic review of non-RCTs with historical controls | |
| Non-RCT with historical controls | |
| Database, registry, or cross-sectional study (Cross-sectional, prevalence studies) | 23 |
| Case series | 3 |
| Retrospective review, modelling | |
| Studies presented at an international conference or other sources of grey literature | |
| Expert opinion | |
| Total | 40 |
RCT refers to randomized controlled trial.
Study classification based on Goodman et al. (52)