Table 6: Evidence Base for CXL for Corneal Thinning Disorders*.
| Effectiveness-Keratoconus | Longitudinal Pre-Post Cohorts | 6 reports | 264 patients |
| Comparative Pre-Post Cohorts – Untreated | 5 reports | 145 patients | |
| Comparative Pre-Post Cohort – Control Group | 1 report | 10 patients | |
| RCT (KC and Post-Lasik ectasia) | 1 report | 58 patients | |
| Effectiveness-Post-Lasik-Ectasia | Longitudinal Pre-Post Cohorts | 4 reports | 66 patients |
| CXL-Plus: (CXL +ICRS) | Longitudinal Pre-Post Cohorts | 6 reports | 91 patients |
| CXL-Plus: (CXL + PRK) | Longitudinal Pre-Post Cohorts | 8 reports | 74 patients |
| CXL-Plus: (CXL +IOL) | Case Reports | 2 reports | 12 patients |
| Safety | Safety and Recovery Series | 18 reports | 668 patients |
| Complication Case reports | 14 reports | 15 patients |
*
CXL indicates corneal collagen cross-linking; ICRS, intrastromal corneal ring segment; IOL, intraocular lens implant; PRK, photorefractive keratectomy